Genetic variant regulates arthritis severity

Lamiot [creativecommons license] via Wikimedia Commons

Lyme disease, caused by the spirochete Borrelia burgdorferi, is the most prevalent arthropod-borne illness in the US. Disease severity varies greatly, with up to 60% of untreated patients developing a self-limiting, inflammatory arthritis. Even after appropriate antibiotic therapy, 10% of patients may develop chronic arthritis lasting months to years. The spectrum of arthritis severity among infected patients suggests that host genetics may contribute to pathogenic outcome.

Lab Anim. (NY) 43, 42 (2014).
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