Boosting bone growth in dwarf mice

George Shuklin [creativecommons license] via Wikimedia Commons

Achondroplasia, the most common form of dwarfism, is characterized by short stature, short limbs and a relatively large head, sometimes resulting in problems with the spine and with hearing and breathing. It is caused by a mutation of the receptor FGFR3, which is involved in the development of bone and brain tissue. The mutation causes FGFR3 to be overstimulated by growth factors, preventing bone cells from maturing and impeding bone formation. Research now shows that in mice carrying the Fgfr3 mutation, a model of achondroplasia, injection of a ‘decoy’ receptor, sFGFR3, prevents growth factors from binding with the mutant receptor. The treatment restored normal bone growth, prevented skeletal defects and reduced mortality in the mutant mice (Sci. Transl. Med. 5, 203ra124; 2013).

Lab Anim. (NY) 42, 402 (2013).
view full text (login required)

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

%d bloggers like this: