Mouse models of prion diseases

Jensflorian [creativecommons license] via Wikimedia Commons

Prion diseases are unusual, infectious, potentially deadly, neurodegenerative diseases caused by transmission and toxic accumulation of misshapen prion protein (PrP) in the brain. A lack of animal models that accurately recapitulate prion disease pathology has impeded our understanding in this area; therefore, the characterization of new mouse models of fatal familial insomnia (FFI) and Creutzfeld-Jakob disease (CJD), two prion diseases that are fatal in humans, represents a welcome advance.

Lab Anim. (NY) 42, 345 (2013).
view full text (login required)
Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: