Multi-Hit model for tumor development

Jpbrody at en.wikipedia [Public domain] from Wikimedia Commons

Decades of cancer research have shown that development of most tumors requires a combination of several genetic mutations. A wide array of such combinations has been implicated in tumorigenesis, and determining which combinations are the most troublesome has been tedious. Now a new mouse model seems poised to facilitate more rapid testing of mutation combinations and hence to accelerate the identification of those with the greatest oncogenic potential.

Lab Anim. (NY) 41, 242 (2012).
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