Primate model brings new hope for stroke treatment

Peter Gronemann [creativecommons license] via Wikimedia Commons

Despite much promising animal research on protecting the brain after stroke, no treatments have yet proven to be effective in humans. This disconnect has contributed to both a lack of confidence in the relevance of animal models for certain types of medical research and a growing concern that stroke-related brain damage may not be avoidable in higher-order mammals such as humans. To bridge this gap, a team of researchers led by Michael Tymianski (Toronto Western Hospital Research Institute, Ontario, Canada) has developed a primate model of stroke by occluding the middle cerebral artery in cynomolgus macaques (Macaca fascicularis). Because primates share behavioral, genetic and anatomical characteristics with humans, success in treating stroke in primates should be a more reliable predictor of success in humans.

Lab Anim. (NY) 41, 114 (2012).
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