Fructokinase isoforms face off in metabolic syndrome

Ewen [Public domain] via Wikimedia Commons

Dietary intake of fructose is associated with obesity, metabolic syndrome and nonalcoholic fatty liver disease in humans, and fructose intake can induce metabolic syndrome in rats and in humans. These effects seem to be independent of excessive energy consumption and increased body weight. To investigate the mechanism linking fructose intake with metabolic syndrome, a research team led by Richard J. Johnson (University of Colorado Denver, Aurora) took a closer look at fructose metabolism in mice.

Lab Anim. (NY) 41, 90 (2012).
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