Missteps in animal behavioral models of anxiety

Rama [creativecommons license] via Wikimedia Commons

Animal models of human disorders are often used for testing therapeutic drugs, but in some cases, the results fail to translate into clinically relevant treatments, a growing concern for biomedical research. Scientists are working hard to identify and address the causes underlying such clinical failures. Among them are Ehud Fonio (Weizmann Institute of Science, Rehovot, Israel), Yoav Benjamini and Ilan Golani (both of Tel Aviv University, Israel), who recently reported that the standard set-up used for studying chronic anxiety disorders is flawed in several ways. The typical study design measures anxiety in the wrong mouse at the wrong time, claims the group (PLoS One 7, e48414; 2012 and Nat. Methods 9, 1167–1170; 2012).

Lab Anim. (NY) 42, 41 (2013).
view full text (login required)
Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: