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In liver disease, the balance between regeneration of healthy tissue and scar formation (or fibrosis) is disrupted. Hepatocyte regeneration gives way to fibrosis, leading to cirrhosis and cancer. The mechanisms that control this balance are poorly characterized; a better understanding may lead to better management strategies for chronic liver disease. Now, a study led by Derek A. Mann (Newcastle University, UK) in collaboration with colleagues at Newcastle and at Institut National de la Santé et de la Recherche Médicale (Paris, France) shows that serotonin is involved in regulating this balance.
Lab Anim. (NY) 41, 5 (2012).
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