Nevit Dilmen [creativecommons license] via Wikimedia Commons
The cytokines are a large, varied group of signaling molecules involved in development, immune responses and cellular communication. Dysregulation of cytokines has been implicated in depression, Alzheimer’s disease, arthritis, cancer and inflammatory bowel disease (IBD). In IBD, cytokines activate the immune system, causing chronic intestinal inflammation (colitis). But recent research led by Charles A. Dinarello (University of Colorado Denver, Aurora) and Jesús Rivera-Nieves (University of California at San Diego, La Jolla) changes our understanding of cytokines’ role in colitis.
Lab Anim. (NY) 40, 290 (2011).
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