Thomas W. Geisbert, Boston University School of Medicine [creativecommons license] via Wikimedia Commons
Outbreaks of Ebola virus infection are associated with hemorrhagic fever and high mortality rates. There are currently no preventive or protective treatments for Ebola infections, although some progress has been made in vaccine development. Development of strategies for managing infection once a person has been exposed to the virus has been much slower. One research group previously reported that small interfering RNAs (siRNAs) targeting the Ebola virus could protect guinea pigs from infection. Although rodent studies are useful in identifying prospective treatments for Ebola, efficacy in guinea pigs may not accurately predict efficacy in primates because guinea pigs have relatively low susceptibility to Ebola infection. Therefore, the group, led by Thomas W. Geisbert (Boston University School of Medicine, MA), assessed the efficacy of siRNA treatment against Ebola infection in rhesus macaques.
Lab Anim. (NY) 39, 197 (2010).
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