Abitua [Public domain] via Wikimedia Commons
Treacher Collins syndrome (TCS) is a craniofacial development disorder that affects roughly 1 in 50,000 people. It is characterized by underdeveloped facial bones, which frequently results in a sunken appearance in the middle of the face, a prominent nose, a very small jaw and chin and downward-slanting eyes; some affected individuals also have cleft palate and malformed or absent ears. Now, researchers have found a way to prevent development of the disorder in a mouse model by inhibiting the function of p53, a tumor suppressor protein.
Lab Anim. (NY) 37, 100 (2008).
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