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Recent experiments in rats have elucidated the mechanism of action underlying uveitis, one of the world’s leading causes of blindness in humans, and have identified a new avenue for its treatment. Uveitis, inflammation of the tissue layer below the outer surface of the eye (uvea), which includes the iris, can be caused by autoimmune disease, infection or toxin exposure. It is the primary cause of severe visual impairment in humans, accounting for 5–15% of cases of total blindness in the US and a higher proportion of those cases in developing countries.
Lab Anim. (NY) 36, 8 (2007).
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