Would you rather be wrinkly or bald? Researchers at Washington University in St. Louis recently described the positional cloning of a spontaneous mutation in wrinkle-free mice (wrfr), grafted skin from which is defective in hair growth. The homozygous mutant mice have extremely thick and tight skin with no wrinkles, but don’t throw out that wrinkle cream yet!Nat. Genet. 34, 11 (2003).